Aug 08, 2025
3 min read
They identify changes in brain cholesterol transport in Alzheimer's patients associated with APOE4 genetic variants
Subscriptions are the most important for Eurons for keeping and good work, if they move their transport or gather, there is a problem.Researchers have found the financial transmission of the brain, the terminal disease is lemonitic, and this change is usually this disease.
They can also reduce their ability to support patients with the Spanish Institute, led by Spanish institutes, led by members of Spanish research and diabetes by members of the Biological Research and Diabetes Department.
Lipoproteins Zinbrospinal Patients with Alzheimer
"We have long known that people with an APOE4 variant, especially through homozygous, have a very high risk of promoting Alzheimer, but so far it is not known why. Our research shows that one of the factors may be influenced by the neurons in the presence of this variant to capture cholesterol, which reaches the brain.
Cholesterol is mixed in membranes, synaptic gears and in the production of myelin in neurons.Unlike other members, the brain does not get cholesterol in brain because the fish prevents it."All necessary cholesterol is produced locally and in the gallosocirus particles, it delivers it to neurons from gliaples.He fails, he will not get the structural and functional resources they need, "said Dr. Tendo.
This error may be related to apoe4 genetic version.
According to the I. I. IT IR SAIT UP, researchers are counting the more alternatives of the 10 people in ALOBUHER or 10 people give up the liquid in the brain in the brain.The other, the beds flownets held to college, nerve potacim in Alzoney areas decided to be a strange.
Given this result, the team wanted to figure out whether this deficiency could be genetics."In our sample, most patients were heteroziguts because of the Ape4 option, and we found out that cholesterol was smaller." When we tested them in neural products, we saw that those containing APOE4 were much less cholesterol.It forced us to think that this option can play a direct role in dysfunction.
In examples of reviewed patients, the cholesterol collection is lower than the Apoe4 variant shows
In addition, scientists have performed a detailed proteinomic analysis of brain grade lipoproteins.239 239 proteins associated with these particles, 27 have changed in patients with Alzheimer's disease.Interestingly, none of these differences directly affected proteins associated with cholesterol metabolism. More complex than we thought, and there may be other mechanisms associated with inflammation, cellular adhesion or degradation of proteins that can also affect the development of the disease, ”adds Dr. Tondo.
"Efficient delivery of cholesterol in neurons is essential for its function and maintenance. This process is addressed to Alzheimer's disease. A special in the presence of the APOE4, the first author of this study, explains." This could contribute to neuronal vulnerability and its progressive degeneration. "
"This study does not allow cholesterol insurance is the cause of clever disease, but it can be a reason to help in neurological damage"
Dr.Tondo you should be sober: "This study does not allow cholesterol deficiency is the direct cause of the disease, but it may be one of the factors that contributes to neuronal destruction. In any case, it will open a very kind -friendly line to explore the brain's lipid metabolism, especially in humans."
Whether the development of RichSie Group Syndrome is also given to the act of development of deed of development of development.As the problem of the Nauroral metitoric issue can also have a way to improve metabolism.
